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Transgenic mouse lines

For more information on characterizations of these transgenic lines, see the Transgenic Catalog whitepaper in documentation.

Mouse Line Example Description
Emx1-IRES-Cre;Camk2a-tTA;Ai93(TITL-GCaMP6f) Emx1-IRES-Cre;Camk2a-tTA;Ai93(TITL-GCaMP6f) fluorescence expression GCaMP6f is widespread in excitatory neurons in the neocortex, striatum and hippocampus.
Slc17a7-IRES2-Cre;Camk2a-tTA;Ai93(TITL-GCaMP6f) Slc17a7-IRES2-Cre;Camk2a-tTA;Ai93(TITL-GCaMP6f) fluorescence expression GCaMP6f is expressed strongly throughout the cortex, hippocampus, olfactory bulb and anterior olfactory nuclei. Scattered expression in striatum. Enriched in restricted populations in pons, superior colliculus and anterodorsal nucleus of thalamus.
Slc17a7-IRES2-Cre;Camk2a-tTA;Ai94(TITL-GCaMP6s) Slc17a7-IRES2-Cre;Camk2a-tTA;Ai94(TITL-GCaMP6s) fluorescence expression GCaMP6s is expressed strongly throughout the cortex, hippocampus, olfactory bulb and anterior olfactory nuclei. Scattered expression in striatum. Enriched in restricted populations in pons, superior colliculus and anterodorsal nucleus of thalamus.
Cux2-CreERT2;Camk2a-tTA;Ai93(TITL-GCaMP6f) Cux2-CreERT2;Camk2a-tTA; Ai93(TITL- GCaMP6f) fluorescence expression GCaMP6f expression is enriched in cortical layers 2, 3 and 4 as well as in thalamus, midbrain, pons, medulla, and cerebellum.
Rorb-IRES2-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Rorb-IRES2-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) fluorescence expression GCaMP6f expression is predominantly in excitatory neurons in cortical layer 4 (dense) and layers 5/6 (sparse), as well as in superior colliculus and thalamus.
Scnn1a-Tg3-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Scnn1a-Tg3-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) fluorescence expression GCaMP6f is predominantly expressed in excitatory neurons in cortical layer 4 and in restricted populations within the cortex, thalamus, and in cerebellum.
Nr5a1-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Nr5a1-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) fluorescence expression GCaMP6f is predominantly expressed in excitatory neurons in cortical layer 4 and in restricted populations within the hypothalamus.
Fezf2-CreER;Ai148(TIT2L-GC6f-ICL-tTA2) Fezf2-CreER;Ai148(TIT2L-GC6f-ICL-tTA2) fluorescence expression GCaMP6f is strongly expressed in cortical layer 5 and some layer 6 as well as basolateral amygdala and scattered expression in pyramidal cell layers of hippocampus.
Tlx3-Cre_PL56;Ai148(TIT2L-GC6f-ICL-tTA2) Tlx3-Cre_PL56;Ai148(TIT2L-GC6f-ICL-tTA2) fluorescence expression GCaMP6f expression is enriched in layer 5a of cortex and in restricted populations of pons and medulla.
Rbp4-Cre_KL100;Camk2a-tTA;Ai93(TITL- GCaMP6f) Rbp4-Cre_KL100;Camk2a-tTA;Ai93(TITL- GCaMP6f) fluorescence expression GCaMP6f is predominantly expressed in excitatory neurons in cortical layer 5 as well as dentate gyrus.
Ntsr1-Cre_GN220;Ai148(TIT2L-GC6f-ICL-tTA2) Ntsr1-Cre_GN220;Ai148(TIT2L-GC6f-ICL-tTA2) fluorescence expression GCaMP6f expression is specific to cortical layer 6 neurons.
Sst-IRES-Cre;Ai148(TIT2L-GC6f-ICL-tTA2) Sst-IRES-Cre;Ai148(TIT2L-GC6f-ICL-tTA2) fluorescence expression GCaMP6f is expressed in scattered cells throughout the brain. Localized areas of enrichment include restricted populations in thalamus, amygdala, midbrain, hindbrain, cortical subplate, and Purkinje cell layer.
Vip-IRES-Cre;Ai148(TIT2L-GC6f-ICL-tTA2) Vip-IRES-Cre;Ai148(TIT2L-GC6f-ICL-tTA2) fluorescence expression GCaMP6f is expressed in scattered cells throughout the brain. Enriched expression in superficial cortical layers and restricted populations in hindbrain and midbrain.
Pvalb-IRES-Cre;Ai162(TIT2L-GC6s-ICL-tTA2) Pvalb-IRES-Cre;Ai162(TIT2L-GC6s-ICL-tTA2) fluorescence expression GCaMP6s is expressed in restricted and/or sparse populations within the cerebellum, medulla, pons, midbrain, cortex, hippocampus, thalamus, and striatum.
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