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Transgenic mouse lines

For more information on characterizations of these transgenic lines, see the Transgenic Catalog whitepaper in documentation.

Mouse Line Example Description
Cux2-CreERT2;Camk2a-tTA;Ai93(TITL- GCaMP6f) Cux2 thumbnail ea5f72cbc0a4ae6fd7f737cb1a68966347ec24655cb45aeb0c797d0bea5bfc9f In the Cux2-CreERT2 transgenic line, cre expression is enriched in cortical layers 2, 3 and 4 as well as in thalamus, midbrain, pons, medulla, and cerebellum, and is regulated by tamoxifen administration.
Rorb-IRES2-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Rorb thumbnail 72294c42955afba30fd8404b05bcb8403bfd5df541215b94e64c809d0afaa2e8 In the Rorb-IRES2-Cre line, cre expression is predominantly in excitatory neurons in cortical layer 4 (dense) and layers 5/6 (sparse), as well as in superior colliculus and thalamus.
Scnn1a-Tg3-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Scnn1a thumbnail 79fe79018b8039dcdd07a33289f842d66bcace2b7b262fbb0d28a85cbeef5e87 In the Scnn1a-Tg3-Cre line, cre expression is predominantly in excitatory neurons in cortical layer 4 and in restricted populations within the cortex, thalamus, and in cerebellum.
Nr5a1-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Nr5a1 thumbnail 0a832b19d5b51536c6e7e6ec6e6f35cfab0c2bc589193fe8b70701ceca9ab0fc In the Nr5a1-Cre line, cre expression is predominantly in excitatory neurons in cortical layer 4 and in restricted populations within the hypothalamus.
Rbp4-Cre_KL100;Camk2a-tTA;Ai93(TITL- GCaMP6f) Rbp4 thumbnail 7d2765e97559c637dfbcccfd1c8e8510bbd041d837724d4444d7618e8672bfaf In the Rbp4-Cre_KL100 line, cre expression is predominantly in excitatory neurons in cortical layer 5 as well as dentate gyrus.
Emx1-IRES-Cre;Camk2a-tTA;Ai93(TITL- GCaMP6f) Emx1 thumbnail 0cc9bf827f117e7aed85dabfc69030817523765f7cb95bc5f4bfddff237d9895 In the Emx1-IRES-Cre line, cre expression is widespread in excitatory neurons in the neocortex, striatum and hippocampus.